Limitless IGCSE Biology
14.1.8 Synapse Structure - Past Paper Practice
Examination Instructions
- • Section A (Paper 2): Diagram labeling and multiple choice questions
- • Section B (Paper 4): Structured theory questions requiring specific keywords
- • Section C (Paper 6): Experimental design, calculations, and practical skills
- • Click "Reveal Answer" to check your response against the mark scheme
- • Use precise Cambridge terminology: vesicles, receptor proteins, synaptic cleft
Section A: Paper 2 - Labeling & MCQ
The diagram shows a synapse. Label the structure indicated by the arrow that stores neurotransmitter molecules.
On the same diagram, label the synaptic cleft / synaptic gap.
Which structure in the pre-synaptic neurone provides energy (ATP) for recycling neurotransmitters?
What is the approximate width of the synaptic cleft?
Which of the following is found on the post-synaptic membrane?
Section B: Paper 4 - Structured Theory
State the function of mitochondria in the synaptic knob.
Identify the structure that neurotransmitter molecules bind to on the post-synaptic neurone.
Explain why there are many mitochondria in the pre-synaptic neurone but not in the post-synaptic neurone.
Describe the structure of a vesicle and state what it contains.
Suggest why the synaptic cleft is so narrow (approximately 20 nm).
Section C: Paper 6 - Experimental Design
A student observes a prepared slide of a synapse under a microscope at 400× magnification. The synaptic cleft measures 8 mm on the image. Calculate the actual width of the synaptic cleft. Show your working.
Compare the width of a typical axon (10 μm) with the width of the synaptic cleft (20 nm). How many times wider is the axon?
A scientist wants to investigate the number of vesicles in the pre-synaptic knob. Suggest a suitable method for counting vesicles.
In an experiment, a drug blocks receptor proteins on the post-synaptic membrane. Predict the effect on nerve impulse transmission.
Explain one safety precaution when using a microscope to observe prepared slides of nervous tissue.
Cambridge Grade Boundaries
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